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KMID : 0043319900130040359
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Archives of Pharmacal Research
1990 Volume.13 No. 4 p.359 ~ p.364
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Effects of Brazilin on Glucose Metabolism in Isolated Soleus Muscles from Streptozotocin Induced Diabetic Rats
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Moon CK
Lee SH/Chung JH/Won HS/Kim JY/Khil LY/Moon CH
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Abstract
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The present study was performed to evaluate the hypoglycemic mechanism of brazilin. Brazilin significantly reduced plasma glucose level in streptozotocin induced diabetic rats and this effect seems to be mediated by extrapancreatic effects rather than by pacreatic effect because no significant changes were observed in plasma insulin levels. The rates of glycogen synthesis, glycolysis and glucose oxidation in soleus muscle were markedly increased following brazilin treatment to diabetic animals. Glucose transport seemed to be increased by the treatment of brazilin. Brazilin did not affect insulin binding to muscles from streptozotocin induced diabetic rats. These results suggest that potentiation of peripheral glucose utilization may be one of the major causes of hypoglycemic action of brazilin.
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